Project ID: W4SNQ7HR49RL

Investigators: Angelique c Paulk

Dataset Size: 461.61 GB

Files: 35468

Description:

This intracranial data set is included in the below publication investigating single pulse stimulation responses in the human brain: Paulk AC, Zelmann R, Crocker B, Widge AS, Dougherty DD, Eskandar EN, et al. Local and distant cortical responses to single pulse intracranial stimulation in the human brain are differentially modulated by specific stimulation parameters. Brain Stimul 2022. 15: 15:491–508. Available from: https://www.sciencedirect.com/science/article/pii/S1935861X22000456 Highlights of the publication include: •Intracranial single pulse electrical stimulation (SPES) response increases with increased pulse duration mostly near the stimulation site. •SPES response varies nonlinearly with injected current with an effect of distance from the stimulation site. •SPES near the grey-white boundary and 90° to the nearest cortical axis induces larger local responses, but white matter stimulation produces larger distant responses. •The relationship between SPES location and responses depends on brain region stimulated. The work was funded by NIH grants MH086400, DA026297, and EY017658 to ENE, MH109722, NS100548, and MH111872 to ASW, NS100548 to DDD, and ECOR, NINDS K24-NS088568 to SSC and Tiny Blue Dot Foundation to SSC, ACP, and RZ. A United States Department of Energy Computational Sciences Graduate Fellowship [DE-FG02-97ER25308] supported BC. Some of this research was sponsored by the U.S. Army Research Office and Defense Advanced Research Projects Agency (DARPA) under Cooperative Agreement Number W911NF-14-2-0045 issued by ARO contracting office in support of DARPA's SUBNETS Program. The views and conclusions contained in this document are those of the authors and do not represent the official policies, either expressed or implied, of the funding sources. The raw data included here also includes data from two other previous publications: Basu I, Robertson MM, Crocker B, Peled N, Farnes K, Vallejo-Lopez DI, Deng H, Thombs M, Martinez-Rubio C, Cheng JJ, McDonald E, Dougherty DD, Eskandar EN, Widge AS, Paulk AC, Cash SS (2019) Consistent Linear and Non-Linear Responses to Electrical Brain Stimulation Across Individuals and Primate Species. Brain Stimulation. 12: 877-892. Crocker B, Ostrowski L, Williams ZM, Dougherty DD, Eskandar EN, Widge AS, Chu CJ, Cash SS, Paulk AC. (2021) Local and Distant responses to single pulse electrical stimulation reflect different forms of connectivity. NeuroImage. 237:118094.

For questions about this dataset, contact apaulk@mgh.harvard.edu

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