Project Details

Project Details

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ACUTE MODULATION OF STEREOTYPED HIGH FREQUENCY OSCILLATIONS WITH A CLOSED-LOOP BRAIN INTERCHANGE SYSTEM IN DRUG RESISTANT EPILEPSY

Mayo Clinic (Nuri Ince)

Project ID: 1UH3NS117944

Investigators: Nuri Ince

Dataset Size: 369.94 GB

Files: 1489

Description:

Overall, this proposal will investigate the functional utility of stereotyped HFOs by capturing them with a new implantable system (Brain Interchange - BIC of CorTec), which can sample neural data at higher rates >=1kHz and deliver targeted electrical stimulation to achieve seizure control. In contrast to current closed-loop systems (RNS), which wait for the seizure to start before delivering stimulation, the BIC system will monitor the spatial topography and rate of stereotyped HFOs and deliver targeted stimulation to these HFO generating areas to prevent seizures from occurring. If the outcomes of our research in acute setting become successful, we will execute a clinical trial and run our methods with the implantable BIC system in a chronic ambulatory setting.


For questions about this dataset, contact ince.nuri@mayo.edu

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